Avian Influenza: A Persistent Threat to Global Health



Avian influenza, also known as bird flu, is a viral disease that primarily affects birds but can also infect other animals, including humans. Avian influenza viruses belong to the Orthomyxoviridae family and are classified into several subtypes based on their surface proteins: hemagglutinin (H) and neuraminidase (N). The most well-known subtypes of avian influenza viruses are H5N1, H7N9, and H9N2.

History and Spread

The first discovery of an avian influenza virus occurred in the early 1900s, but the avian influenza pandemic became a major concern only in recent decades. In 1997, Hong Kong witnessed the first major H5N1 outbreak, leading to the mass culling of birds to control the spread of the virus. Since then, avian influenza outbreaks have occurred in various parts of the world, including Asia, Europe, Africa, and North America.

Symptoms and Diagnosis in Birds

Symptoms of avian influenza in birds can range from mild to severe, potentially leading to high mortality. Common symptoms include:

  • Decreased appetite and egg production
  • Lethargy and ruffled feathers
  • Swelling of the face and comb
  • Respiratory problems

Diagnosis of avian influenza is made through laboratory tests such as polymerase chain reaction (PCR) and virus isolation from samples taken from infected birds.

Transmission to Humans

Avian influenza is transmitted to humans mainly through direct contact with infected birds or surfaces contaminated with their secretions. Although human-to-human transmission is rare, it is possible under certain conditions. Symptoms in humans can range from flu-like symptoms (fever, cough, sore throat) to severe forms such as pneumonia, acute respiratory distress syndrome, and in some cases, death.

Control and Prevention Measures

To control the spread of avian influenza, stringent biosecurity measures are necessary on poultry farms. These measures include:

  • Controlling access to farms and maintaining strict hygiene for personnel
  • Monitoring the health of birds and promptly reporting any signs of disease
  • Vaccinating birds in high-risk areas

Additionally, educating the public and farmers about the risks of avian influenza and prevention measures is essential. Health authorities must be prepared to respond quickly to avian influenza outbreaks through the culling of infected birds and quarantine.

Avian influenza remains a significant threat to global health, affecting both birds and humans. Effective control of this disease requires international collaboration, continuous surveillance, and rigorous preventive measures. Research continues to develop more effective vaccines and treatments in hopes of reducing the impact of this dangerous disease.

Avian Influenza and Its Impact on the Human Body


Avian influenza, caused by avian influenza viruses, is primarily a bird disease, but certain subtypes like H5N1 and H7N9 can infect humans, causing severe illness. Although human infections are rare, they are often severe and have a high mortality rate. This article details how avian influenza affects the human body, associated symptoms, and possible complications.

Mechanism of Infection

Avian influenza viruses are transmitted to humans through direct contact with infected birds, their excretions, or contaminated environments. Infection begins when the virus enters the body through the nasal, oral, or conjunctival mucosa. From there, the virus replicates in the epithelial cells of the respiratory tract and, in some cases, can invade other organs.

Initial Symptoms

Initially, symptoms of avian influenza resemble those of seasonal flu and include:

  • High fever (above 38°C)
  • Cough
  • Sore throat
  • Muscle and joint pain
  • Headache
  • Weakness and fatigue

Disease Progression and Complications

In many cases, avian influenza can quickly progress to severe forms, manifesting as:

  • Pneumonia: Inflammation of the lungs, visible on X-rays, is one of the most common complications. Patients experience difficulty breathing, chest pain, and sputum-producing cough.
  • Acute Respiratory Distress Syndrome (ARDS): A severe complication leading to respiratory failure, often requiring mechanical ventilation.
  • Sepsis: A systemic inflammatory response to infection that can lead to multiple organ dysfunction and even death.
  • Acute Kidney Failure: Severe kidney impairment sometimes requiring dialysis.
  • Encephalitis: Brain inflammation causing neurological symptoms such as confusion, seizures, and coma.

Immune Response

The immune response to avian influenza virus infection involves the activation of the innate and adaptive immune systems. Cytokines and chemokines are produced in large quantities, which can lead to a “cytokine storm,” an excessive inflammatory reaction contributing to the severity of the disease.

Treatment and Preventive Measures

Treatment for avian influenza includes antivirals such as oseltamivir (Tamiflu) and zanamivir (Relenza), which are more effective if administered within the first 48 hours of symptom onset. In severe cases, supportive care in intensive care units is essential.

Preventive Measures

Preventing human infection with avian influenza viruses relies on avoiding contact with infected birds and strict hygiene measures:

  • Frequent handwashing with soap and water
  • Using masks and personal protective equipment in affected areas
  • Thorough cooking of poultry meat and eggs
  • Avoiding live bird markets in affected regions

Avian influenza poses a significant threat to human health due to its potential to cause severe illness and serious complications. Although infections are rare, continued vigilance, surveillance, and rigorous preventive measures are essential to minimize risks and protect public health.

What to Do If You Have Consumed Potentially Avian Influenza-Contaminated Food

Consuming food that may be infected with avian influenza virus is a major concern, especially in regions where outbreaks are common. However, it is important to understand that the risk of infection from consuming well-cooked poultry meat or eggs is extremely low. Avian influenza viruses are sensitive to heat and are destroyed by proper cooking. Nevertheless, if you suspect that you have consumed potentially contaminated food, there are certain precautions and actions you can take.

Symptoms to Watch For

If you have consumed suspicious food, it is important to be alert for symptoms of avian influenza. These include:

  • High fever (above 38°C)
  • Cough
  • Sore throat
  • Muscle and joint pain
  • Headache
  • Respiratory difficulties
  • Weakness and fatigue

Symptoms can appear within 2 to 8 days after exposure. If you exhibit any of these symptoms after consuming suspicious food, it is essential to seek medical attention immediately.

Immediate Steps to Take

  1. Monitor Symptoms: Observe if any of the aforementioned symptoms appear. Stay vigilant in the days following the consumption of suspicious food.
  2. Consult a Doctor: If symptoms appear, contact a doctor or visit a medical facility immediately. Inform medical personnel about the consumption of suspicious food and the symptoms you are experiencing.
  3. Avoid Contact with Others: To prevent potential virus spread, avoid close contact with other people and follow isolation measures recommended by health authorities.
  4. Practice Rigorous Hygiene: Wash your hands frequently with soap and water for at least 20 seconds, especially after coughing or sneezing. Use alcohol-based sanitizers if soap and water are unavailable.

Preventing Future Exposure

To prevent the risk of exposure to avian influenza viruses through food, follow these recommendations:

  • Cook Poultry and Eggs Thoroughly: Ensure poultry meat is cooked to an internal temperature of at least 75°C and that eggs are fully cooked. The avian influenza virus is destroyed at high temperatures.
  • Avoid Consuming Raw or Undercooked Food: Avoid consuming raw or soft-boiled eggs and undercooked poultry meat.
  • Kitchen Hygiene: Clean and disinfect kitchen surfaces and utensils after handling raw poultry. Wash your hands with soap and water after handling such food.
  • Safe Food Sources: Purchase poultry meat and eggs from safe and verified sources, preferably from suppliers who adhere to hygiene and biosecurity standards.

Although the risk of infection with avian influenza through the consumption of well-cooked food is very low, it is important to remain vigilant and follow food safety measures. If you suspect you have consumed potentially contaminated food, monitor your symptoms and seek medical attention immediately if signs of illness appear. Practicing rigorous hygiene and following cooking recommendations can significantly contribute to preventing exposure to avian influenza viruses.

Source: WHO

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